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COVID-19: Modern will call for emergency use of vaccine

Editorial office. Peninsula 360 Press [P360P].

The biotechnology company, Moderna, announced Monday that it plans to apply for emergency use authorization from the U.S. Food and Drug Administration (FDA) and conditional approval from the European Medicines Agency (EMEA) for its COVID-19 vaccine.

This is because the main efficacy analysis of the Phase 3 mRNA-1273 study conducted in 196 cases confirms the high efficacy observed in the first interim analysis, as the data indicate an efficacy of 94.1 percent. 

The U.S. company said in a statement that the safety data continues to accumulate and the study continues to be monitored by a Data Safety Monitoring Board (DSMB). 

"This positive primary analysis confirms the ability of our vaccine to prevent COVID-19 disease with an efficacy of 94.1 percent and, more importantly, the ability to prevent severe COVID-19 disease," said Stéphane Bancel, CEO of Moderna. 

"We believe our vaccine will provide a powerful new tool that can change the course of this pandemic and help prevent serious illness, hospitalization and death," he added.

In turn, the company said it is now planning a phase 3 study, known as the COVE study, for which it has recruited more than 30,000 participants and is being conducted in collaboration with the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, and the Advanced Biomedical Research and Development Authority.

The primary endpoint of the Phase 3 COVE study, he said, is based on analysis of confirmed and adjudicated COVID-19 cases starting two weeks after the second dose of vaccine. 

"The efficacy of the vaccine has been demonstrated in the first interim analysis with a total of 95 cases according to the pre-set efficacy criteria. Today's primary analysis was based on 196 cases, of which 185 cases of COVID-19 were observed in the placebo group versus 11 cases observed in the mRNA-1273 group, resulting in a point estimate of vaccine efficacy of 94.1 percent," he said.

He added that a secondary endpoint analyzed severe cases of COVID-19 and included 30 severe cases - as defined in the study protocol - in this analysis. 

In that regard, he explained that all 30 cases occurred in the placebo group and none in the mRNA-1273 group, since, to date, there was only one death related to COVID-19 in the study, which occurred in the placebo group.

Moderna explains that effectiveness was consistent across age, race, ethnicity, and gender demographics, as the 196 cases of COVID-19 included 33 older adults - over 65 years old - and 42 participants who identified themselves as belonging to diverse communities - including 29 Hispanics or people from the Latino community, six African Americans, four Asian Americans, and three multiracial participants.

According to the company, it has not identified any new serious safety issues, while, according to a previous analysis, the most common adverse reactions included pain at the injection site, fatigue, myalgia, arthralgia, headache and erythema/rediness at the injection site. 

"Adverse reactions increased in frequency and severity in the mRNA-1273 group after the second dose," he said.

It is worth noting that the Company has already begun the ongoing review process with the EMA, Health Canada, SwissMedic, the UK's Medicines and Healthcare Regulatory Agency (MHRA), Israel's Ministry of Health and the Health Sciences Authority in Singapore, and intends to seek Pre-Qualification or Emergency Use Listing with the World Health Organization (WHO).

Additionally, Moderna announced that the FDA's Advisory Committee on Vaccines and Related Biological Products will review the safety and efficacy data package for mRNA-1273 likely on Thursday, Dec. 17. 

The Company expects that the U.S. Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices will make a recommendation on immunization priorities. 

Moderna anticipates that the shipment of mRNA-1273 to designated distribution points will occur shortly after an emergency use authorization is granted.

By the end of 2020, the Company expects to have approximately 20 million doses of mRNA-1273 available, while it remains on track to manufacture 500 million to 1 billion doses globally by 2021.

HIV and SARS-CoV-2: challenges to be overcome for migrants and Latinos

Pamela Cruz. Peninsula 360 Press [P360P].

In February 2019, the U.S. government updated its national goals to eradicate the human immunodeficiency virus (HIV) epidemic by 2030, and although there has been significant progress in the fight against it in recent years, this trend has not been reflected in the Hispanic and Latino community.

In addition, another epidemic, SARS-CoV-2, is presenting many challenges, especially for undocumented immigrants, who are more vulnerable to getting sick from COVID-19 because they are afraid to seek medical care due to their immigration status.

On World AIDS Day, which is commemorated on December 1 each year, the National Institute of Health (NIH) reported that there are one million people in the United States who are either HIV-positive or have AIDS. The number of cases reported annually peaked in 1993, when approximately 80,000 people were infected.

While from 2014 to 2018, according to the Center for Disease Control and Prevention (CDC), the annual number of diagnoses among adults and adolescents decreased by 7.0 percent; however, it has increased among other groups, such as Latinos and Hispanics.

A report from the Center for Latino Adolescent and Family Health, released in 2019, indicates that although the estimated HIV incidence in the U.S. has decreased 6.0 percent since 2010, among Latino and Hispanic populations, it has increased 14 percent.

Similarly, he reports that the annual number of Latinos newly diagnosed with HIV has increased by 7.0 percent between 2012 and 2016, in contrast to overall new annual HIV diagnoses across the United States, which have decreased by 4.0 percent.

When looking at the number of incidents by community, among the African-American community there has been a drop of 5.0 percent; among Caucasians it dropped 8.0 percent, while among Hispanics and Latinos it had an increase of 7.0 percent.

Within the Hispanic and Latino community, a key population affected by HIV is 13-25 years old, which has seen a 9.0 percent increase in new diagnoses, compared to, for example, African-American youth of the same age, which has fallen 10 percent.

The research also adds that men from the Latino and Spanish-speaking communities who have sex with men represented the greatest increase in estimates of annual infections in terms of race, ethnicity, and therefore are the group with the greatest transmission of the HIV virus, which causes AIDS.

Similarly, men aged 25-34 who have sex with other men, and who are of Hispanic or Latino origin, accounted for the largest increase in estimated annual infections of all population groups.

The Center for Adolescent and Family Health adds that some of the drivers of the epidemic may be the stigma associated with HIV, gaps in knowledge about the disease and its risks, distrust of the health care system, lack of health care coverage, as well as homophobia and transphobia.

The disparities among communities with HIV and AIDS are not the only challenge to achieving the goals of defeating the epidemic by 2030. Today, there is another epidemic that has magnified the problems for the Latino community: COVID-19.

According to Heriberto Soto-Sanchez, director of the Hispanic Forum on AIDS, the COVID-19 pandemic has disrupted services to curb the HIV epidemic, and even threatens the future of organizations fighting to eradicate the disease. 

COVID-19 has exacerbated many challenges that immigrants already face, since in addition to dealing with HIV/AIDS - depending on their case - they have to deal with the stress of finding or keeping their jobs, having enough money to pay for housing expenses, as well as trying to stay alive.

Because, he said, stress can trigger an increase in viral load, which can make a person living with HIV much more susceptible to diseases such as COVID-19, this can be an extremely complex situation. 

Winnie Byanyima, Executive Director of UNAIDS, notes about the pandemic by COVID-19: "We have a unique opportunity to reinvent health systems," so that we are better equipped to create healthier and more resilient societies. 

"We can take advantage of this opportunity and learn from AIDS and COVID-19 to implement substantial changes that will enable us to develop rights-based, equitable and people-centred health systems," he said.

Half Moon Bay: First Latino Immigrant on the Council

Pamela Cruz. Peninsula 360 Press [P360P]

After years of dealing with discrimination and racism, Joaquin Jimenez, a Mexican by birth, will be the first Latino immigrant to serve on the Half Moon Bay Council..

Little by little, the now California State University sociology graduate made the city his home, since he arrived there when he was just a child, and his passion for the city finally materialized when he won a seat in the last election on Nov. 3.

The 47-year-old Jimenez said he was humbled by the community's support and vowed to fight to represent everyone in Half Moon Bay, including those who have felt excluded in the past. 

Proud of his Latino heritage and community, he said he will represent the voice of the Spanish-speaking community by "implementing their voice.

Currently, Joaquin works with Ayudando Latinos A Sonar, or ALAS, and has been a liaison for Puente de la Costa Sur, a community resource center and outreach coordinator for farmworkers. 

In the past, he co-founded the city's Latino Advisory Council and has worked as a teacher in the Hatch School Immersion Program for the Cabrillo Unified School District. 

He spent 15 years as a juvenile corrections officer in the San Mateo County Juvenile Probation Department.

This was Jimenez's first time running for political office, and with 62.76 percent of the vote, Jimenez defeated Adam Eisen.

On housing, the future city councillor will seek to identify locations for more affordable and sustainable space in the centre of the area, within walking distance of schools, shops, work and clinics. 

He said the city is in contact with property owners in Half Moon Bay to look for possible new housing locations, although the COVID-19 pandemic has delayed the search. 

On agriculture and education, he said he wants to find a more sustainable way to farm and protect the environment for future generations, in addition to addressing low Latino graduation rates and improving educational inequities that lead to disadvantaged people living below the poverty line. 

He also wants to have a conversation about implementing ethnic studies into the school's curriculum, and hopes to find trade school opportunities in the area to create the next generation of plumbers and electricians.

COVID-19: Forty-nine change of venue

Pamela Cruz. Peninsula 360 Press [P360P]

The San Francisco Forty-Niners will play at least their next two home games at State Farm Stadium in Glendale, Arizona, because Santa Clara County announced Saturday new restrictive measures related to COVID-19.

"The Cardinals organization, State Farm Stadium and league officials have been supportive and accommodating as we work through the many logistical issues involved in relocating NFL games," the Bay Area team said in a statement.

As such, the Forty-Niners will host the Buffalo Bills in Arizona for a Monday night game on Dec. 7, as well as Washington on Sunday, Dec. 13. 

The Forty-Niners are still working to define where they will practice for the next few weeks. While their preference is to stay in the Bay Area to practice during the week and fly to Arizona for the games, this plan may not be logistically feasible.

For his part, coach Kyle Shanahan said he was disappointed by the way they found out they would have to find a new home to play in the coming weeks: during their flight to face the Los Angeles Rams over the weekend. 

"I get it: they made that decision and we have to deal with that, but to find out through a tweet or a press conference ... I've got a whole plane coming up to me, wives, girlfriends, family members and kids saying they found out we might be out all of December."

"We are human like everybody else, and it's a big problem to leave your family for the whole of December, a big problem, as everybody knows... We need to find a place where we can feel safe and stay because we won't be able to go to our homes anymore to make them safe. So, we will have to stay in a hotel or somewhere."

Notably, Santa Clara County announced Saturday that the number of residents who have been infected with COVID-19 and the number of hospitalized patients continues to climb significantly, reaching record levels since the start of the pandemic.

On that day alone, 760 new cases and 239 hospitalizations were recorded, of which 71 are in the intensive care unit. So, to reduce the likelihood of an increase in hospitalizations that exceeds the capacity of hospitals, were announced several changes to the directives that accompany the Risk Reduction Order of the Public Health Officer.

The changes include requiring certain sectors to modify their operations to increase security, reducing the number of people allowed on the premises at any one time, and reducing the size of outdoor gatherings.

For professional, collegiate and youth sports, all recreational activities involving physical contact or proximity to persons outside the home, including all contact sports, were temporarily prohibited.

San Mateo: Plastic ban in 2021

Pamela Cruz. Peninsula 360 Press [P360P].

The city of San Mateo aims to be more friendly to the environment, which is why se seeks a ban on single-use plastic products in restaurants, supermarkets and grocery stores that sell prepared food.

This was reported by The Daily Journal, which said that the initiative will be presented to the San Mateo County Council in the first months of 2021.

With this initiative, the newspaper noted, San Mateo will require the use of compostable utensils instead of those made of plastic, and the regulation of these for those products prepared in stores; however, you can continue to buy plastic items for use elsewhere: forks, toothpicks or spoons, among others.

According to the note, the ban would affect 428 establishments in the locality. However, the pandemic and the low attendance at these establishments would allow the owners to gradually adapt to this new modality.

While the initiative will be introduced in late January or early February of next year, the city is expected to begin enforcing the law by 2022, according to the city's deputy mayor, Eric Rodriguez.

The goal of allowing the initiative to take legal effect for up to two years is to ensure that San Mateo restaurants are not disadvantaged and have a plan of action in place prior to implementation.

It was noted that the city plans to meet later this year with restaurateurs and owners of convenience stores and places that sell prepared foods to alert them about possible changes that will take place next year.

The local newspaper said San Mateo County will be responsible for enforcing the ban, including the financial costs, which encouraged the city to participate.

With that said, the City of San Mateo plans to make its ordinance similar to the county's, which passed this year, require the use of compostable non-plastic compostable items instead of plastic products.

According to the initiative, non-plastic components are required for the manufacture of plates, bowls, cups, food trays, boxes, deli containers and other packaging.

Restaurants and stores must also use non-plastic, compostable straws, stirrers, utensils and toothpicks, and accessories such as chopsticks, utensils and condiment sachets would only be provided upon request or in self-service areas.

Councilmembers Diane Papan and Rick Bonilla agreed that, while the measure is good for the future, it is important to start in 2022 to first find solutions to the plastic waste problem.

Finally, they hope that the next year will represent a window of opportunity before the law is enforced, which will help restaurants prepare and give them time to establish alternatives to plastic options, as it is a challenge to run a restaurant at this time.

We Vote: Alicia Aguirre

Christian Carlos. Peninsula 360 Press.

This week, in the company of our presenters, Connie Guerrero and Rudy EspinozaPeninsula 360 Press brings you another installment of We Vote, an online television show that aims to showcase the San Francisco Peninsula and Bay Area community, local community members, election experts, but most importantly those people, elected through the ballot, who are charged with representing the will of the people, the backbone of our society.

On this occasion, Alicia Aguirre, member of Redwood City Council District 7. She is a professor and PhD in Social Anthropology; she was also the first Latina mayor in the history of the city, this is her last term in office after 30 years of dedicated service to her community.

During the program, Connie Guerrero and Rudy Espinoza, addressed current issues such as the electoral process for the renewal of Council members, as well as the challenges that Alicia Aguirre had to face during her campaign, mainly because of the COVID-19 pandemic.

In addition, it is important to inform the community about the actions she will take during her last term during the next four years. Alicia Aguirre, talks to us in depth about the three axes that, she says, are key to maintaining the welfare of the community: housing, transportation and attention to our youth, sheltered under a vision of equity.

The COVID-19 pandemic, he says, is an urgent health emergency in Redwood City, as this past week, it has been upgraded to a purple alert - the Public Health Department's highest alert. Aguirre noted the importance of supporting the community in maintaining their businesses, their right to housing and food for vulnerable groups.

We invite you to follow the next editions of We Vote every week. Follow us on our social networks: YouTube, Facebook, Twitter and Instagram and don't miss the live broadcasts offered by Peninsula 360 Press.

San Mateo passes to Purple level in view of increase in cases by Covid-19

By Pamela Cruz

The state of California announced that, starting tomorrow, San Mateo County will be upgraded to Purple Level 1, the most restrictive of the Covid-19 reopening measures, in order to prevent an increase in the number of infections.

While the new statewide stay home order, which prohibits county residents from leaving their homes from 10:00 pm to 5:00 am, will take effect on Monday night, November 30.

San Mateo County referred in a statement that under Level 1 restrictions, businesses and activities that had been operating indoors, such as places of worship, movie theaters, gyms and museums, must move outdoors or close. 

Similarly, shopping malls and all retail stores shall operate at no more than 25 percent of their capacity, while indoor meetings between members of different households are prohibited.

When it comes to outdoor meetings, these may include people from only three households, as long as they are held outside of the restricted hours of 10:00 pm to 5:00 am.

According to state officials, more restrictive measures are needed to control the recent increase in reported cases of coronavirus in both the Bay Area and the state as a whole. 

The county health department said there was an 85 percent increase in new cases of VIDOC-19 from October to November, and the drop in the purple level is due to the county's adjusted rate of 7.6 new cases per 100,000 population.

"We haven't seen figures like this in quite a while. We really need to reverse this incredibly worrying trend. We can do that as long as we follow common sense health and safety practices," said County Administrator Mike Callagy.

"We need everyone to do their part to keep our community safe. We urge everyone to stay home for the holidays. I know it's a sacrifice, but the best way to show your family that you love them is to stay home and be safe," he added.

It should be noted that the new order to stay at home is more limited than that of spring. The new order was announced by the state on November 19, came into effect on November 21 and will remain in effect until December 21.

Residents may still go out alone or with members of their own household as long as they do not participate in any interaction with members of other households, or if their employment is essential, such as in grocery stores. 

The order also requires that all non-essential businesses and restaurants, even if they operate outdoors, complete their operations before 10:00 pm. 

Finally, County Health Officer Scott Morrow recommended avoiding travel this season, as one test may be negative due to the incubation period of the virus, but there is still a risk of exposing others to IDV-19. 

COVID-19: Los Angeles, new restrictions until December 20

Christian Carlos. Peninsula 360 Press [P360P].

Today, the Los Angeles County, California, Department of Public Health issued a statement that, since the average threshold of 4,500 confirmed cases of COVID-19 per day was exceeded, additional and stronger containment measures will be taken to slow the spread of the new SARS-CoV-2 coronavirus, which originated a year ago in a market in Wuhan, China.

In particular, the director of the Los Angeles County Department of Public Health, Dr. Barbara Ferrer, offered her heartfelt condolences to those families who have been affected by this "terrible virus.

"We hope that the residents of Los Angeles County will continue to follow the safety measures of the Department of Public Health, measures that, we know, can stop contagion. Acting with collective urgency is essential if we are to stem this tide," he said, calling on them over the next three weeks to "please stay home as much as possible and not to meet with others outside of your home.

The following measures will come into force as of this Monday, November 30 and will continue for three more weeks, that is, until at least December 20:

  • MeetingsThe following are prohibited: All public and private meetings with individuals who do not belong to the same household. Exceptions are made for religious services and protests, which are rights protected by the Constitution
  • BusinessMasks: Mandatory use of masks and physical distance of at least 6 feet (2 meters):
    • Essential retail business with a 35% maximum occupancy.
    • Non-essential businesses with non-essential retail sales -including shopping centers in closed spaces- with a 20% maximum occupancy rate.
    • Personal care services with a 20% maximum occupancy.
    • Libraries, with a 20% maximum occupancy rate
    • Outdoor training centers with a 50% maximum occupancy
    • Museums, galleries, zoos, aquariums, outdoor botanical gardens with a 50% maximum occupancy.
    • Miniature golf courses, batting cages, go-karts outdoors with 50% maximum occupancy.
  • Outdoor recreation activities will require the mandatory use of a mask -except for swimming-, practicing also physical distancing:
    • Beaches, trails and parks remain open; meetings with people from outside the home are prohibited.
    • Golf courses, tennis courts, archery fields, skate parks, bicycle paths and community gardens remain open to individuals or members of a single family.
    • Community pools can only be opened for stationary swimming limited to one person per lane.
    • Drive-ins/events/parades are allowed as long as the occupants of each car are members of a family.
  • Schools:
    • All schools and day camps remain open following reopening protocols. K-12 schools and day camps with one case of VOC-19 - 3 or more cases in 14 days - must remain closed for 14 days.
  • Full lockdown:
    • Playgrounds (except nursery and school playgrounds)
    • Poker rooms.
    • Due to the high infection ratesThe restaurants, bars, breweries and wine cellars will have to limit their access but not their service: so they can still offer takeaway food. Breweries and wineries remain open for retail sales with an occupancy rate of 20%.

For more information, please visit: http://www.publichealth.lacounty.gov.

U.S. Soccer Talents are Migrants

Editorial office. Peninsula 360 Press [P360P].

If there is one sport in which the United States has not excelled throughout history, it is soccer. The senior team's record is based on titles in the North American and Caribbean region, CONCACAF, where they have won the Gold Cup six times, a runner-up spot at the Confederations Cup in 2009 and a runner-up spot at the 1930 World Cup.

Today's big stars suggest that the US will have too high a ceiling on football, completely changing the dynamics that have generated the national team's reach throughout history.

The one considered the best in the history of the American country is Landon Donovan. A stereotype of an athlete with a winning mentality, offensive skills and great soccer generation. 

The today retired 10 of US Soccer Not only did he generate animosity on the field, but the white phenotypical characteristics, the supremacy speech that he managed throughout his career and the so representative nickname that marked him as "Captain America", contributed to infect generations of mentally solid players, but scarce of resources for the game.

However, today, talent abounds in the U.S., the common denominator involving African-American migrants. Barcelona's recent recruit, Sergiño Dest, comes from a Dutch mother and father from Suriname, an island in the Caribbean. The club's right-back is barely 20 years old and already stands out as one of the regulars in Ronald Koeman's squad. 

Another of the athletes that the Catalan team is profiling to be part of its offensive revolution on the left wing is Konrad de la Fuente, who was born in Miami Florida in 2001. His parents are Haitian, and he is of Dominican Republic descent. At the age of 10, he left for Spain and, although he had the opportunity to wear the Iberian shirt, he preferred to represent the United States, where he made his debut with the senior national team.

One of the most promising of his historical past is Timothy Weah, son of the legendary African player, George Weah, who is also currently president of his country, Liberia. The current Lille player has skills as a centre-forward, has played ten times for the US national team and has scored one goal. Weah Sr. is remembered as the only African player in history to win the Golden Ball, the annual individual award for the best player in the world.

Giovanni Alejandro Reyna is another talent with American nationality, but originally from Durham, England. He currently plays as a midfielder for Borussia Dortmund in the German Bundesliga. His training took place mainly in New York and, at the age of 15, in the 2017-2018 season, he was considered in the New York City FC U-18 team where he contributed with 13 goals in 17 games. 

Borussia Dortmund looked to him to make him part of the German team and his managers said "We only consider bringing in youngsters from abroad when we are 100% confident that the player has the potential to play for the first team.

Christian Pulisic, a Croatian grandfather, represents the U.S. team. He is currently a player with Chelsea F.C., the runner-up in the English championship. He was initially signed in Europe by Borussia Dortmund, where he played from 2016 to 2019. However, he was born and raised in Hershey, Pennsylvania and began his career for PA Classics and Harrisburg City Islanders, during his childhood and teenage years, respectively. 

The talent of the American team promises to compete for important positions in the face of an atypical World Cup, to be played in another field where football did not figure until recently: Qatar 2022.

COVID-19 and elections drive California companies to stock market listing

Pamela Cruz. Peninsula 360 Press [P360].

Several California-based technology companies announced plans to list on the New York Stock Exchange before the end of the year, taking advantage of a market rally following the election, as well as mobility restrictions and remote working.

Firms such as DoorDash, Airbnb, Roblox and Wish, are taking advantage of a market rally after the November 3 elections, which has raised stock indices close to their historical highs, leading to a clear demand in the public market.

Similarly, these companies involved in e-commerce, food delivery and online entertainment, expect to have a busy year-end, with the increase in cases of coronavirus and an economy that has had to adapt to more digital habits. 

Without a doubt, the most anticipated IPO is that of Airbnb, through which it hopes to raise three billion dollars by selling its shares, despite the fact that the firm has been severely affected by the pandemic and its outlook looked uncertain for the future. 

It should be noted that Airbnb expected to make its public offering in early 2020, but the business was halted at the end of March. However, it is currently showing a revival as mobility restrictions are lifted, with users choosing to work remotely in holiday homes.

On the other hand, DoorDash is a company similar to Rappi, which operates in the United States and Canada. The firm has been valued at $16 billion and became one of the big winners with the containment measures, which have led people to place more food orders at home.

Thus, for the first nine months of the year, the number of orders rose to 543 million, compared to 181 million for the same period in 2019; while revenues rose from $239 million to $879 million for the period.

As for Roblox, it is one of the video game companies that has registered the highest growth during the pandemic, as its revenues grew 91 percent in the third quarter of 2020, to just over $242 million.

In addition, its daily active users reached 36.2 million in September and game hours doubled to more than eight thousand, as people spend more time at home, and can even organize virtual birthday parties and other meetings in the app.

Finally, the popular e-commerce company Wish, is a firm that is valued at just over 11 billion and has over 100 million active users. Its third quarter revenues increased 33 percent to 606 million.

Wish was exposed during the early days of the pandemic because most of its traders are based in China, so the interruption in deliveries caused revenues to fall in the first quarter of the year, but they are seeing a recovery.

2021 also looks like a promising year for IPOs on Wall Street, with investors waiting for the online brokerage firm RobinHood to make its debut during the first half of next year.

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